5d8e: Difference between revisions

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-'''Unreleased structure'''
-The entry 5d8e is ON HOLD  until Paper Publication
+==crystal structure of SSB from homo sapiens==
+<StructureSection load='5d8e' size='340' side='right' caption='[[5d8e]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors: Li, Y.H., Gao, Z.Q., Dong, Y.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5d8e]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D8E FirstGlance]. <br>
-Description: crystal structure of SSB from homo sapiens
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d8f|5d8f]]</td></tr>
-[[Category: Gao, Z.Q]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d8e OCA], [http://pdbe.org/5d8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d8e RCSB], [http://www.ebi.ac.uk/pdbsum/5d8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d8e ProSAT]</span></td></tr>
-[[Category: Dong, Y.H]]
+</table>
-[[Category: Li, Y.H]]
+== Function ==
+[[http://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN]] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Dong, Y H]]
+[[Category: Gao, Z Q]]
+[[Category: Li, Y H]]
+[[Category: Dna binding protein]]
+[[Category: Single-strand dna binding]]