Survivin: Difference between revisions
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== Function == | == Function == | ||
'''Survivin''' or '''apoptosis inhibitor 4''' (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation. | '''Survivin''' or '''apoptosis inhibitor 4''' (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation<ref>PMID:9850056</ref>.. | ||
== Disease == | == Disease == | ||
IAP4 is found in human cancer cells and can serve as a cancer marker and as a target for chemotherapy. | IAP4 is found in human cancer cells<ref>PMID:18032822</ref>. and can serve as a cancer marker and as a target for chemotherapy<ref>PMID:22680927</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:59, 6 September 2016
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3D structures of survivin3D structures of survivin
Updated on 06-September-2016
ReferencesReferences
- ↑ Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20. PMID:9850056
- ↑ Zaffaroni N, Costa A, Pennati M, De Marco C, Affini E, Madeo M, Erdas R, Cabras A, Kusamura S, Baratti D, Deraco M, Daidone MG. Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma. Cell Oncol. 2007;29(6):453-66. PMID:18032822
- ↑ Rodel F, Sprenger T, Kaina B, Liersch T, Rodel C, Fulda S, Hehlgans S. Survivin as a prognostic/predictive marker and molecular target in cancer therapy. Curr Med Chem. 2012;19(22):3679-88. PMID:22680927