Spermidine Synthase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

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-<StructureSection load='3c6k' size='350' side='right' caption='Structure of human spermidine synthase complex with spermidine and deoxymethyladenosine (PDB entry [[3c6k]])' scene='49/497058/Cv/2'>
+<StructureSection load='3c6k' size='350' side='right' caption='Structure of human spermidine synthase complex with spermidine and deoxymethyladenosine (PDB entry [[3c6k]])' scene=''>
+<font color='red'><b>Under construction!</b></font><br />
 == Function ==
-Polyamines are essential in all branches of life. '''Spermidine synthase''' (putrescine aminopropyltransferase, PAPT) (SPS) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine<ref>PMID:17585781</ref>.  SPS catalyzes the transfer of aminopropyl group from decarboxylated S-adenosylmethionine (SAM) to the amine acceptor spermidine.
+Polyamines are essential in all branches of life. '''Spermidine synthase''' (putrescine aminopropyltransferase, PAPT) (SPS) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine.
+[[1inl]] - The crystal structure of the PAPT from ''Thermotoga maritima'' (TmPAPT) has been solved to 1.5 A resolution.
-== Disease ==
+The structure of TmPAPT in a complex with adoDATO ([[1jq3]]) can also be found on this site.
-SPS deficiency causes the intellectual disability Snyder-Robinson syndrome<ref>PMID:21318891</ref>.
 ==Structural highlights ==
-<scene name='49/497058/Cv/5'>SPS active sited contains the substrate spermidine</scene><ref>PMID:18367445</ref>. Water molecules shown as red spheres.
+SPS active sited contains the substrate spemidine<ref>PMID:18367445</ref>.
 </StructureSection>
 ==3D structures of spermidine synthase==
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 *Ternary complexes of spermidine synthase
-**[[3c6k]], [[4cxm]], [[4uoe]] - hSPS + methylthioadenosine + spermidine<br />
+**[[3c6k]] - hSPS + methylthioadenosine + spermidine<br />
 **[[3c6m]] - hSPS + methylthioadenosine + spermine<br />
-**[[2pt6]], [[3rie]], [[4bp3]], [[4bp1]] - PfSPS + inhibitor + methylthioadenosine<br />
+**[[2pt6]], [[3rie]] - PfSPS + inhibitor + methylthioadenosine<br />
 **[[2pt9]] - PfSPS + inhibitor + SAM derivative<br />
-**[[4cwa]] - PfSPS + inhibitor + ethanol derivative<br />
-**[[4yv0]], [[4yv1]], [[4yv2]], [[4yuv]], [[4yuw]], [[4yux]], [[4yuy]], [[4yuz]] - TcSPS + inhibitor + SAM derivative<br />
 }}
 == References ==