4ur0: Difference between revisions
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==Crystal structure of the PCE reductive dehalogenase from S. multivorans in complex with trichloroethene== | ==Crystal structure of the PCE reductive dehalogenase from S. multivorans in complex with trichloroethene== | ||
<StructureSection load='4ur0' size='340' side='right' caption='[[4ur0]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4ur0' size='340' side='right' caption='[[4ur0]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uqu|4uqu]], [[4ur1|4ur1]], [[4ur2|4ur2]], [[4ur3|4ur3]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uqu|4uqu]], [[4ur1|4ur1]], [[4ur2|4ur2]], [[4ur3|4ur3]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tetrachloroethene_reductive_dehalogenase Tetrachloroethene reductive dehalogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.97.1.8 1.97.1.8] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tetrachloroethene_reductive_dehalogenase Tetrachloroethene reductive dehalogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.97.1.8 1.97.1.8] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ur0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ur0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ur0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ur0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ur0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ur0 OCA], [http://pdbe.org/4ur0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ur0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ur0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ur0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4ur0" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Dehalogenase|Dehalogenase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 21:17, 11 August 2016
Crystal structure of the PCE reductive dehalogenase from S. multivorans in complex with trichloroetheneCrystal structure of the PCE reductive dehalogenase from S. multivorans in complex with trichloroethene
Structural highlights
Publication Abstract from PubMedOrganohalide-respiring microorganisms can use a variety of persistent pollutants including trichloroethene (TCE) as terminal electron acceptors. The final two-electron transfer step in organohalide respiration is catalyzed by reductive dehalogenases. Here we report the x-ray crystal structure of PceA, an archetypal dehalogenase from Sulfurospirillum multivorans, as well as structures of PceA in complex with TCE and product analogs. The active site harbors a deeply buried norpseudo-B12 cofactor within a nitroreductase fold, also found in a mammalian B12 chaperone. The structures of PceA reveal how a cobalamin supports a reductive haloelimination exploiting a conserved B12-binding scaffold capped by a highly variable substrate-capturing region. Structural basis for organohalide respiration.,Bommer M, Kunze C, Fesseler J, Schubert T, Diekert G, Dobbek H Science. 2014 Oct 2. pii: 1258118. PMID:25278505[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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