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==Regulatory domain structure of NMB2055 (MetR) a LysR family regulator from N. meningitidis== | ==Regulatory domain structure of NMB2055 (MetR) a LysR family regulator from N. meningitidis== | ||
<StructureSection load='4ab5' size='340' side='right' caption='[[4ab5]], [[Resolution|resolution]] 2.51Å' scene=''> | <StructureSection load='4ab5' size='340' side='right' caption='[[4ab5]], [[Resolution|resolution]] 2.51Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ab5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4ab5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neimi Neimi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AB5 FirstGlance]. <br> | ||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ab6|4ab6]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ab6|4ab6]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ab5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ab5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ab5 RCSB], [http://www.ebi.ac.uk/pdbsum/4ab5 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ab5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ab5 OCA], [http://pdbe.org/4ab5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ab5 RCSB], [http://www.ebi.ac.uk/pdbsum/4ab5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ab5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4ab5" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Neimi]] | ||
[[Category: Owens, R J]] | [[Category: Owens, R J]] | ||
[[Category: Ren, J]] | [[Category: Ren, J]] | ||
Revision as of 20:40, 11 August 2016
Regulatory domain structure of NMB2055 (MetR) a LysR family regulator from N. meningitidisRegulatory domain structure of NMB2055 (MetR) a LysR family regulator from N. meningitidis
Structural highlights
Publication Abstract from PubMedThe crystal structure of the regulatory domain of NMB2055, a putative MetR regulator from Neisseria meningitidis, is reported at 2.5 A resolution. The structure revealed that there is a disulfide bond inside the predicted effector-binding pocket of the regulatory domain. Mutation of the cysteines (Cys103 and Cys106) that form the disulfide bond to serines resulted in significant changes to the structure of the effector pocket. Taken together with the high degree of conservation of these cysteine residues within MetR-related transcription factors, it is suggested that the Cys103 and Cys106 residues play an important role in the function of MetR regulators. Structure of the regulatory domain of the LysR family regulator NMB2055 (MetR-like protein) from Neisseria meningitidis.,Sainsbury S, Ren J, Saunders NJ, Stuart DI, Owens RJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):730-7. Epub, 2012 Jun 22. PMID:22750853[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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