3ux9: Difference between revisions
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==Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus== | ==Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus== | ||
<StructureSection load='3ux9' size='340' side='right' caption='[[3ux9]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='3ux9' size='340' side='right' caption='[[3ux9]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ux9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3ux9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UX9 FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IFNA1, IFNA13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IFNA1, IFNA13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ux9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ux9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ux9 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ux9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux9 OCA], [http://pdbe.org/3ux9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ux9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ux9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ux9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/IFNA1_HUMAN IFNA1_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<ref>PMID:1634550</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3ux9" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[ | *[[3D structures of monoclonal antibody|3D structures of monoclonal antibody]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Liang, M F]] | [[Category: Liang, M F]] | ||
[[Category: Liang, W]] | [[Category: Liang, W]] | ||