4bdb: Difference between revisions
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==Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)== | ==Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)== | ||
<StructureSection load='4bdb' size='340' side='right' caption='[[4bdb]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4bdb' size='340' side='right' caption='[[4bdb]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bdb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4bdb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BDB FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=ODO:4-[(E)-C-METHYL-N-OXIDANYL-CARBONIMIDOYL]BENZENE-1,3-DIOL'>ODO</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=ODO:4-[(E)-C-METHYL-N-OXIDANYL-CARBONIMIDOYL]BENZENE-1,3-DIOL'>ODO</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gxc|1gxc]], [[2cn5|2cn5]], [[2cn8|2cn8]], [[2w0j|2w0j]], [[2w7x|2w7x]], [[2wtc|2wtc]], [[2wtd|2wtd]], [[2wti|2wti]], [[2wtj|2wtj]], [[2xbj|2xbj]], [[2xk9|2xk9]], [[2xm8|2xm8]], [[2xm9|2xm9]], [[2ycf|2ycf]], [[2ycq|2ycq]], [[2ycr|2ycr]], [[2ycs|2ycs]], [[2yiq|2yiq]], [[2yir|2yir]], [[2yit|2yit]], [[4a9r|4a9r]], [[4a9s|4a9s]], [[4a9t|4a9t]], [[4a9u|4a9u]], [[4bda|4bda]], [[4bdc|4bdc]], [[4bdd|4bdd]], [[4bde|4bde]], [[4bdf|4bdf]], [[4bdg|4bdg]], [[4bdh|4bdh]], [[4bdi|4bdi]], [[4bdj|4bdj]], [[4bdk|4bdk]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gxc|1gxc]], [[2cn5|2cn5]], [[2cn8|2cn8]], [[2w0j|2w0j]], [[2w7x|2w7x]], [[2wtc|2wtc]], [[2wtd|2wtd]], [[2wti|2wti]], [[2wtj|2wtj]], [[2xbj|2xbj]], [[2xk9|2xk9]], [[2xm8|2xm8]], [[2xm9|2xm9]], [[2ycf|2ycf]], [[2ycq|2ycq]], [[2ycr|2ycr]], [[2ycs|2ycs]], [[2yiq|2yiq]], [[2yir|2yir]], [[2yit|2yit]], [[4a9r|4a9r]], [[4a9s|4a9s]], [[4a9t|4a9t]], [[4a9u|4a9u]], [[4bda|4bda]], [[4bdc|4bdc]], [[4bdd|4bdd]], [[4bde|4bde]], [[4bdf|4bdf]], [[4bdg|4bdg]], [[4bdh|4bdh]], [[4bdi|4bdi]], [[4bdj|4bdj]], [[4bdk|4bdk]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bdb RCSB], [http://www.ebi.ac.uk/pdbsum/4bdb PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bdb OCA], [http://pdbe.org/4bdb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bdb RCSB], [http://www.ebi.ac.uk/pdbsum/4bdb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bdb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4bdb" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Aherne, G W]] | [[Category: Aherne, G W]] |