Ribonucleotide reductase: Difference between revisions
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<StructureSection load='1xjg' size='350' side='right' caption='Class II ribonucleotide reductase dimer complex with DATP, UDP (stick models) and Mg+2 ion (green) (PDB entry [[1xjg]])' scene=''> | <StructureSection load='1xjg' size='350' side='right' caption='Class II ribonucleotide reductase dimer complex with DATP, UDP (stick models) and Mg+2 ion (green) (PDB entry [[1xjg]])' scene=''> | ||
== Function == | == Function == | ||
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**[[3hnd]] – hRNR M1 + GDP + TTP<BR /> | **[[3hnd]] – hRNR M1 + GDP + TTP<BR /> | ||
**[[3hne]], [[3hnf]] – hRNR M1 + ATP + TTP<BR /> | **[[3hne]], [[3hnf]] – hRNR M1 + ATP + TTP<BR /> | ||
**[[2wgh]] - hRNR M1 + ATP + Mg<BR /> | **[[2wgh]], [[5d1y]] - hRNR M1 + ATP + Mg<BR /> | ||
**[[4x3v]] - hRNR M1 + inhibitor<br /> | |||
**[[3paw]] - yRNR R1 + ATP<BR /> | **[[3paw]] - yRNR R1 + ATP<BR /> | ||
**[[3k8t]] - yRNR R1 + ADP analog<BR /> | **[[3k8t]] - yRNR R1 + ADP analog<BR /> | ||
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**[[2xof]], [[3n37]], [[3n38]], [[2alx]], [[1piy]], [[1r65]], [[1mxr]], [[1jqc]], [[1jpr]], [[1av8]], [[1xik]], [[1rib]], [[4m1f]] – EcRNR R2 <BR /> | **[[2xof]], [[3n37]], [[3n38]], [[2alx]], [[1piy]], [[1r65]], [[1mxr]], [[1jqc]], [[1jpr]], [[1av8]], [[1xik]], [[1rib]], [[4m1f]] – EcRNR R2 <BR /> | ||
**[[1yfd]], [[1piz]], [[1pj0]], [[1pj1]], [[1pm2]], [[1pim]], [[1piu]], [[1biq]], [[2av8]], [[1pfr]] - EcRNR R2 (mutant) <BR /> | **[[1yfd]], [[1piz]], [[1pj0]], [[1pj1]], [[1pm2]], [[1pim]], [[1piu]], [[1biq]], [[2av8]], [[1pfr]] - EcRNR R2 (mutant) + Fe<BR /> | ||
**[[3hf1]], [[2vux]], [[2uw2]], [[4djn]] – hRNR M2<BR /> | **[[3hf1]], [[2vux]], [[2uw2]], [[4djn]] – hRNR M2<BR /> | ||
**[[3mjo]], [[3dhz]], [[1oqu]], [[1kgn]], [[1kgo]], [[1kgp]] – RNR R2 – ''Corynebacterium ammoniagenes''<BR /> | **[[3mjo]], [[3dhz]], [[1oqu]], [[1kgn]], [[1kgo]], [[1kgp]] – RNR R2 – ''Corynebacterium ammoniagenes''<BR /> | ||
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**[[3n39]], [[3n3a]], [[3n3b]] – EcRNR R2 + NrdI<BR /> | **[[3n39]], [[3n3a]], [[3n3b]] – EcRNR R2 + NrdI<BR /> | ||
**[[1rnr]] – EcRNR R2 (mutant) + dopa<BR /> | **[[1rnr]] – EcRNR R2 (mutant) + dopa<BR /> | ||
**[[5ci4]] – EcRNR R2 (mutant) + FE2O<br /> | |||
**[[5ci3]], [[5ci0]], [[5ci1]], [[5ci2]] – EcRNR R2 (mutant) + fluoro-tyrosine + FE<sub>2</sub>O<br /> | |||
**[[1w69]] – mRNR R2 + acetate<br /> | **[[1w69]] – mRNR R2 + acetate<br /> | ||
**[[4bmo]], [[4bmp]] - BcRNR + | **[[4bmo]], [[4bmp]] - BcRNR + NrdI <br /> | ||
*Ribonucleotide reductase small+large subunit | *Ribonucleotide reductase small+large subunit | ||
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**[[2xak]], [[2xap]], [[2xo4]], [[2xo5]] - EcRNR R1+ R2 peptide<BR /> | **[[2xak]], [[2xap]], [[2xo4]], [[2xo5]] - EcRNR R1+ R2 peptide<BR /> | ||
**[[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR /> | **[[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR /> | ||
**[[2bq1]] - StRNR R1+ R2 | **[[5cns]], [[5cnt]], [[5cnv]], [[5cnu]] - EcRNR R1 + R2 + 2 nucleotides<br /> | ||
**[[2bq1]] - StRNR R1+ R2<br /> | |||
**[[5im3]] - RNR + dATP – ''Pseudomonas aeruginosa''<br /> | |||
*'''Class II ribonucleotide reductase''' | *'''Class II ribonucleotide reductase''' | ||
**[[1xjf]] – TmRNR + DATP – ''Thermotoga maritima''<BR /> | **[[1xjf]], [[4col]] – TmRNR + DATP – ''Thermotoga maritima''<BR /> | ||
**[[1xjg]] - TmRNR + | **[[4coi]], [[4com]], [[4con]] – TmRNR<br /> | ||
**[[1xjg]], [[1xjk]], [[1xje]], [[1xjn]], [[4coj]] - TmRNR + 2 nucleotides<BR /> | |||
**[[1xjj]] - TmRNR + GTP<BR /> | **[[1xjj]] - TmRNR + GTP<BR /> | ||
**[[1xjm]] - TmRNR + TTP<BR /> | **[[1xjm]] - TmRNR + TTP<BR /> | ||
**[[3o0n]] - TmRNR + TTP + Co + Mg + deoxyadenosine + B12<br /> | **[[3o0n]] - TmRNR + TTP + Co + Mg + deoxyadenosine + B12<br /> | ||
**[[3o0o]] - TmRNR + TTP + GDP + Mg + deoxyadenosine + B12<br /> | **[[3o0o]] - TmRNR + TTP + GDP + Mg + deoxyadenosine + B12<br /> | ||
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**[[1h78]], [[1h79]], [[1h7a]], [[1hk8]] – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4<br /> | **[[1h78]], [[1h79]], [[1h7a]], [[1hk8]] – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4<br /> | ||
**[[1h7b]] – T4RNR (mutant) <br /> | **[[1h7b]] – T4RNR (mutant) <br /> | ||
**[[4u3e]] – TmRNR large subunit <br /> | |||
}} | }} | ||
== References == | == References == | ||