Ribonucleotide reductase: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='1xjg' size='350' side='right' caption='Class II ribonucleotide reductase dimer complex with DATP (stick | <StructureSection load='1xjg' size='350' side='right' caption='Class II ribonucleotide reductase dimer complex with DATP, UDP (stick models) and Mg+2 ion (green) (PDB entry [[1xjg]])' scene=''> | ||
== Function == | == Function == | ||
'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides<ref>PMID:16756507</ref>. There are 3 classes of RNR.<br /> | '''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides<ref>PMID:16756507</ref>. There are 3 classes of RNR.<br /> | ||
| Line 14: | Line 14: | ||
== Structural highlights == | == Structural highlights == | ||
<ref>PMID:15475969</ref> | Class II RNR is vitamin B12-dependent. The active site which binds the substrate is in a tight pocket and contains conserved residues involved in the catalytic mechanism <ref>PMID:15475969</ref> | ||
</StructureSection> | </StructureSection> | ||