3emi: Difference between revisions
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==Crystal structure of Hia 307-422 non-adhesive domain== | ==Crystal structure of Hia 307-422 non-adhesive domain== | ||
<StructureSection load='3emi' size='340' side='right' caption='[[3emi]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='3emi' size='340' side='right' caption='[[3emi]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3emi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3emi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EMI FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s7m|1s7m]], [[2gr8|2gr8]], [[2gr7|2gr7]], [[3emf|3emf]], [[3emo|3emo]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s7m|1s7m]], [[2gr8|2gr8]], [[2gr7|2gr7]], [[3emf|3emf]], [[3emo|3emo]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3emi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3emi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3emi RCSB], [http://www.ebi.ac.uk/pdbsum/3emi PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3emi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3emi OCA], [http://pdbe.org/3emi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3emi RCSB], [http://www.ebi.ac.uk/pdbsum/3emi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3emi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3emi ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3emi" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bacterium influenzae lehmann and neumann 1896]] | ||
[[Category: Meng, G]] | [[Category: Meng, G]] | ||
[[Category: Waksman, G]] | [[Category: Waksman, G]] | ||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
[[Category: Haemophilus influenzae]] | |||
[[Category: Hia adhesin]] | [[Category: Hia adhesin]] | ||
[[Category: Non-adhesive domain]] | [[Category: Non-adhesive domain]] | ||
[[Category: Trimeric autotransporter]] | [[Category: Trimeric autotransporter]] | ||
Revision as of 10:39, 11 August 2016
Crystal structure of Hia 307-422 non-adhesive domainCrystal structure of Hia 307-422 non-adhesive domain
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe Hia autotransporter of Haemophilus influenzae belongs to the trimeric autotransporter subfamily and mediates bacterial adherence to the respiratory epithelium. In this report, we show that the structure of Hia is characterized by a modular architecture containing repeats of structurally distinct domains. Comparison of the structures of HiaBD1 and HiaBD2 adhesive repeats and a nonadhesive repeat (a novel fold) shed light on the structural determinants of Hia adhesive function. Examination of the structure of an extended version of the Hia translocator domain revealed the structural transition between the C-terminal translocator domain and the N-terminal passenger domain, highlighting a highly intertwined domain that is ubiquitous among trimeric autotransporters. Overall, this study provides important insights into the mechanism of Hia adhesive activity and the overall structure of trimeric autotransporters. Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter.,Meng G, St Geme JW 3rd, Waksman G J Mol Biol. 2008 Dec 26;384(4):824-36. Epub 2008 Oct 11. PMID:18948113[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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