5ir4: Difference between revisions

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'''Unreleased structure'''


The entry 5ir4 is ON HOLD until Paper Publication
==Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group C2221 at 1.48 A resolution==
 
<StructureSection load='5ir4' size='340' side='right' caption='[[5ir4]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5ir4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IR4 FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZPE:(2R)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(TETRADEC-5-ENOYLOXY)PROPYL+(11Z)-OCTADEC-11-ENOATE'>ZPE</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ir4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ir4 OCA], [http://pdbe.org/5ir4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ir4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ir4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ir4 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/LOXA_PSEAE LOXA_PSEAE]] Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.aeruginosa infections.<ref>PMID:14766977</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Banthiya, S]]
[[Category: Kalms, J]]
[[Category: Kuhn, H]]
[[Category: Scheerer, P]]
[[Category: Yoga, E Galemou]]
[[Category: Eicosanoid]]
[[Category: Infectious disease]]
[[Category: Non-heme iron enzyme]]
[[Category: Oxidoreductase]]
[[Category: Protein-phospholipid complex]]

Revision as of 19:26, 10 August 2016

Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group C2221 at 1.48 A resolutionCrystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group C2221 at 1.48 A resolution

Structural highlights

5ir4 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LOXA_PSEAE] Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.aeruginosa infections.[1]

References

  1. ↑ Vance RE, Hong S, Gronert K, Serhan CN, Mekalanos JJ. The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2135-9. Epub 2004 Feb 6. PMID:14766977 doi:http://dx.doi.org/10.1073/pnas.0307308101

5ir4, resolution 1.48Å

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