Retinoid X receptor: Difference between revisions
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<StructureSection load=' | 'right' caption='Structure of human retinoid X receptor α ligand-binding domain tetramer complex with retinoid (PDB entry [[1g5y]])' scene=''> | ||
<StructureSection load='1fby' size='350' side='right' caption='Structure of human retinoid X receptor α ligand-binding domain complex with 9-cis retinoic acid (PDB entry [[1fby]])' scene=''> | |||
== Function == | == Function == | ||
'''Retinoid X receptor''' (RXR) is a nuclear receptor activated by 9-''cis'' retinoic acid. RXR makes a heterodimer with subfamily 1 nuclear receptors including retinoic acid receptor (RAR). In the absence of ligand, the RAR/RXR complex binds the hormone response elements complexed with corepressor protein. Upon binding of the ligand, the corepressor disassociates from the receptor and associates with the coactivator leading to transcription activation. RXR contains a DNA-binding domain (DBD) and ligand-binding domain (LBD)<ref>PMID:22020178</ref>. For additional details on RXR-α see [[RA Mediated T-reg Differentiation]]. | '''Retinoid X receptor''' (RXR) is a nuclear receptor activated by 9-''cis'' retinoic acid. RXR makes a heterodimer with subfamily 1 nuclear receptors including retinoic acid receptor (RAR). In the absence of ligand, the RAR/RXR complex binds the hormone response elements complexed with corepressor protein. Upon binding of the ligand, the corepressor disassociates from the receptor and associates with the coactivator leading to transcription activation. RXR contains a DNA-binding domain (DBD) and ligand-binding domain (LBD)<ref>PMID:22020178</ref>. For additional details on RXR-α see [[RA Mediated T-reg Differentiation]]. | ||
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== Structural highlights == | == Structural highlights == | ||
9-''cis'' retinoid acid binds to RXRα LBD in a hydrophobic pocket. The ligand-binding residues are conserved in the 3 types of RXR | |||
<ref>PMID: | <ref>PMID:10835357</ref>. | ||
</StructureSection> | </StructureSection> | ||