4har: Difference between revisions
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==Crystal Structure of Rubella virus capsid protein (residues 127-277)== | ==Crystal Structure of Rubella virus capsid protein (residues 127-277)== | ||
<StructureSection load='4har' size='340' side='right' caption='[[4har]], [[Resolution|resolution]] 2.66Å' scene=''> | <StructureSection load='4har' size='340' side='right' caption='[[4har]], [[Resolution|resolution]] 2.66Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hbe|4hbe]], [[4hbo|4hbo]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hbe|4hbe]], [[4hbo|4hbo]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Capsid ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11043 RUBV])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Capsid ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11043 RUBV])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4har FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4har OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4har RCSB], [http://www.ebi.ac.uk/pdbsum/4har PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4har FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4har OCA], [http://pdbe.org/4har PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4har RCSB], [http://www.ebi.ac.uk/pdbsum/4har PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4har ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4har" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 02:09, 6 August 2016
Crystal Structure of Rubella virus capsid protein (residues 127-277)Crystal Structure of Rubella virus capsid protein (residues 127-277)
Structural highlights
Publication Abstract from PubMedRubella virus (RV) is a leading cause of birth defects due to infectious agents. When contracted during pregnancy, RV infection leads to severe damage in fetuses. Despite its medical importance, compared with the related alphaviruses, very little is known about the structure of RV. The RV capsid protein is an essential structural component of virions as well as a key factor in virus-host interactions. Here we describe three crystal structures of the structural domain of the RV capsid protein. The polypeptide fold of the RV capsid protomer has not been observed previously. Combining the atomic structure of the RV capsid protein with the cryoelectron tomograms of RV particles established a low-resolution structure of the virion. Mutational studies based on this structure confirmed the role of amino acid residues in the capsid that function in the assembly of infectious virions. Rubella virus capsid protein structure and its role in virus assembly and infection.,Mangala Prasad V, Willows SD, Fokine A, Battisti AJ, Sun S, Plevka P, Hobman TC, Rossmann MG Proc Natl Acad Sci U S A. 2013 Nov 26. PMID:24282305[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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