4doh: Difference between revisions
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==IL20/IL201/IL20R2 Ternary Complex== | ==IL20/IL201/IL20R2 Ternary Complex== | ||
<StructureSection load='4doh' size='340' side='right' caption='[[4doh]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='4doh' size='340' side='right' caption='[[4doh]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4doh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4doh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DOH FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL20, ZCYTO10, UNQ852/PRO1801 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL20, ZCYTO10, UNQ852/PRO1801 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL20RB, DIRS1, UNQ557/PRO1114 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL20RA, UNQ681/PRO1315 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4doh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4doh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4doh RCSB], [http://www.ebi.ac.uk/pdbsum/4doh PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4doh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4doh OCA], [http://pdbe.org/4doh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4doh RCSB], [http://www.ebi.ac.uk/pdbsum/4doh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4doh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/IL20_HUMAN IL20_HUMAN]] Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. | [[http://www.uniprot.org/uniprot/IL20_HUMAN IL20_HUMAN]] Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. [[http://www.uniprot.org/uniprot/I20RA_HUMAN I20RA_HUMAN]] The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. [[http://www.uniprot.org/uniprot/I20RB_HUMAN I20RB_HUMAN]] The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4doh" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Logsdon, N J]] | [[Category: Logsdon, N J]] | ||
[[Category: Walter, M R]] | [[Category: Walter, M R]] | ||
Revision as of 02:04, 6 August 2016
IL20/IL201/IL20R2 Ternary ComplexIL20/IL201/IL20R2 Ternary Complex
Structural highlights
Function[IL20_HUMAN] Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. [I20RA_HUMAN] The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. [I20RB_HUMAN] The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. Publication Abstract from PubMedInterleukin 20 (IL-20) is a pleotropic IL-10 family cytokine that protects epithelial surfaces from pathogens. However, dysregulated IL-20 signaling is implicated in several human pathologies including psoriasis, rheumatoid arthritis, atherosclerosis, and osteoporosis. IL-20, and related cytokines IL-19 and IL-24, designated IL-20 subfamily cytokines (IL-20SFCs), induce cellular responses through an IL-20R1/IL-20R2 (type I) receptor heterodimer, whereas IL-20 and IL-24 also signal through the IL-22R1/IL-20R2 (type II) receptor complex. The crystal structure of the IL-20/IL-20R1/IL-20R2 complex reveals how type I and II complexes discriminate cognate from noncognate ligands. The structure also defines how the receptor-cytokine interfaces are affinity tuned to allow distinct signaling through a receptor complex shared by three different ligands. Our results provide unique insights into the complexity of IL-20SFC signaling that may be critical in the design of mechanistic-based inhibitors of IL-20SFC-mediated inflammatory disease. Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.,Logsdon NJ, Deshpande A, Harris BD, Rajashankar KR, Walter MR Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12704-9. Epub 2012 Jul 16. PMID:22802649[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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