4gd7: Difference between revisions

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==Wild-Type Human Thymidylate Synthase with bound Purpurogallin==
==Wild-Type Human Thymidylate Synthase with bound Purpurogallin==
<StructureSection load='4gd7' size='340' side='right' caption='[[4gd7]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='4gd7' size='340' side='right' caption='[[4gd7]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tys, ts, ok/sw-cl.29 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tys, ts, ok/sw-cl.29 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gd7 RCSB], [http://www.ebi.ac.uk/pdbsum/4gd7 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gd7 OCA], [http://pdbe.org/4gd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gd7 RCSB], [http://www.ebi.ac.uk/pdbsum/4gd7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gd7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==

Revision as of 01:56, 6 August 2016

Wild-Type Human Thymidylate Synthase with bound PurpurogallinWild-Type Human Thymidylate Synthase with bound Purpurogallin

Structural highlights

4gd7 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
NonStd Res:,
Gene:tys, ts, ok/sw-cl.29 (HUMAN)
Activity:Thymidylate synthase, with EC number 2.1.1.45
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.[1]

See Also

References

  1. ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108

4gd7, resolution 2.29Å

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OCA
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