4muj: Difference between revisions

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==Crystal structure of pantothenate synthetase in complex with 2-(2-(benzylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid==
==Crystal structure of pantothenate synthetase in complex with 2-(2-(benzylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid==
<StructureSection load='4muj' size='340' side='right' caption='[[4muj]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
<StructureSection load='4muj' size='340' side='right' caption='[[4muj]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mq6|4mq6]], [[4mue|4mue]], [[4muf|4muf]], [[4mug|4mug]], [[4muh|4muh]], [[4mui|4mui]], [[4mul|4mul]], [[4mun|4mun]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mq6|4mq6]], [[4mue|4mue]], [[4muf|4muf]], [[4mug|4mug]], [[4muh|4muh]], [[4mui|4mui]], [[4mul|4mul]], [[4mun|4mun]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantoate--beta-alanine_ligase Pantoate--beta-alanine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.1 6.3.2.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantoate--beta-alanine_ligase Pantoate--beta-alanine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.1 6.3.2.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4muj RCSB], [http://www.ebi.ac.uk/pdbsum/4muj PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muj OCA], [http://pdbe.org/4muj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4muj RCSB], [http://www.ebi.ac.uk/pdbsum/4muj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4muj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>   
[[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>   
==See Also==
*[[Pantothenate synthetase|Pantothenate synthetase]]
== References ==
== References ==
<references/>
<references/>

Revision as of 01:02, 6 August 2016

Crystal structure of pantothenate synthetase in complex with 2-(2-(benzylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acidCrystal structure of pantothenate synthetase in complex with 2-(2-(benzylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid

Structural highlights

4muj is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Activity:Pantoate--beta-alanine ligase, with EC number 6.3.2.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]

See Also

References

  1. Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627

4muj, resolution 1.92Å

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