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==Co-crystal structure of K72E variant of rat polymerase beta: Enzyme-DNA binary complex== | ==Co-crystal structure of K72E variant of rat polymerase beta: Enzyme-DNA binary complex== | ||
<StructureSection load='3v7k' size='340' side='right' caption='[[3v7k]], [[Resolution|resolution]] 2.27Å' scene=''> | <StructureSection load='3v7k' size='340' side='right' caption='[[3v7k]], [[Resolution|resolution]] 2.27Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3v7k]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3v7k]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V7K FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v7j|3v7j]], [[3v7l|3v7l]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v7j|3v7j]], [[3v7l|3v7l]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v7k RCSB], [http://www.ebi.ac.uk/pdbsum/3v7k PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7k OCA], [http://pdbe.org/3v7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v7k RCSB], [http://www.ebi.ac.uk/pdbsum/3v7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v7k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Buffalo rat]] | ||
[[Category: Jaeger, J]] | [[Category: Jaeger, J]] | ||
[[Category: Rangarajan, S]] | [[Category: Rangarajan, S]] | ||
Revision as of 23:50, 5 August 2016
Co-crystal structure of K72E variant of rat polymerase beta: Enzyme-DNA binary complexCo-crystal structure of K72E variant of rat polymerase beta: Enzyme-DNA binary complex
Structural highlights
Function[DPOLB_RAT] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. See Also |
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