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==CRYSTAL STRUCTURE OF PPO3, A TYROSINASE FROM AGARICUS BISPORUS, IN DEOXY-FORM THAT CONTAINS ADDITIONAL UNKNOWN LECTIN-LIKE SUBUNIT== | ==CRYSTAL STRUCTURE OF PPO3, A TYROSINASE FROM AGARICUS BISPORUS, IN DEOXY-FORM THAT CONTAINS ADDITIONAL UNKNOWN LECTIN-LIKE SUBUNIT== | ||
<StructureSection load='2y9w' size='340' side='right' caption='[[2y9w]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2y9w' size='340' side='right' caption='[[2y9w]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=HO:HOLMIUM+ATOM'>HO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=HO:HOLMIUM+ATOM'>HO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y9x|2y9x]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y9x|2y9x]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosinase Tyrosinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.18.1 1.14.18.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y9w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y9w RCSB], [http://www.ebi.ac.uk/pdbsum/2y9w PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y9w OCA], [http://pdbe.org/2y9w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y9w RCSB], [http://www.ebi.ac.uk/pdbsum/2y9w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y9w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PPO3_AGABI PPO3_AGABI]] Copper-containing oxidase that catalyzes both the o-hydroxylation of monophenols and the subsequent oxidation of the resulting o-diphenols into reactive o-quinones, which evolve spontaneously to produce intermediates, which associate in dark brown pigments. Involved in the initial step of melanin synthesis. Melanins constitute a mechanism of defense and resistance to stress such as UV radiations, free radicals, gamma rays, dehydratation and extreme temperatures, and contribute to the fungal cell-wall resistance against hydrolytic enzymes in avoiding cellular lysis. Fungal pigments are also involved in the formation and stability of spores (By similarity). | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2y9w" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Tyrosinase|Tyrosinase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Agaricus bisporus]] | [[Category: Agaricus bisporus]] | ||
[[Category: | [[Category: Tyrosinase]] | ||
[[Category: Dijkstra, B W]] | [[Category: Dijkstra, B W]] | ||
[[Category: Fusetti, F]] | [[Category: Fusetti, F]] | ||