3p4j: Difference between revisions
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==Ultra-high resolution structure of d(CGCGCG)2 Z-DNA== | ==Ultra-high resolution structure of d(CGCGCG)2 Z-DNA== | ||
<StructureSection load='3p4j' size='340' side='right' caption='[[3p4j]], [[Resolution|resolution]] 0.55Å' scene=''> | <StructureSection load='3p4j' size='340' side='right' caption='[[3p4j]], [[Resolution|resolution]] 0.55Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d48|1d48]], [[1dcg|1dcg]], [[2dcg|2dcg]], [[1i0t|1i0t]], [[1ick|1ick]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d48|1d48]], [[1dcg|1dcg]], [[2dcg|2dcg]], [[1i0t|1i0t]], [[1ick|1ick]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p4j RCSB], [http://www.ebi.ac.uk/pdbsum/3p4j PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4j OCA], [http://pdbe.org/3p4j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p4j RCSB], [http://www.ebi.ac.uk/pdbsum/3p4j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p4j ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3p4j" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 23:13, 5 August 2016
Ultra-high resolution structure of d(CGCGCG)2 Z-DNAUltra-high resolution structure of d(CGCGCG)2 Z-DNA
Structural highlights
Publication Abstract from PubMedThe crystal structure of a Z-DNA hexamer duplex d(CGCGCG)(2) determined at ultra high resolution of 0.55 A and refined without restraints, displays a high degree of regularity and rigidity in its stereochemistry, in contrast to the more flexible B-DNA duplexes. The estimations of standard uncertainties of all individually refined parameters, obtained by full-matrix least-squares optimization, are comparable with values that are typical for small-molecule crystallography. The Z-DNA model generated with ultra high-resolution diffraction data can be used to revise the stereochemical restraints applied in lower resolution refinements. Detailed comparisons of the stereochemical library values with the present accurate Z-DNA parameters, shows in general a good agreement, but also reveals significant discrepancies in the description of guanine-sugar valence angles and in the geometry of the phosphate groups. High regularity of Z-DNA revealed by ultra high-resolution crystal structure at 0.55 A.,Brzezinski K, Brzuszkiewicz A, Dauter M, Kubicki M, Jaskolski M, Dauter Z Nucleic Acids Res. 2011 Aug 1;39(14):6238-48. Epub 2011 Apr 1. PMID:21459852[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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