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EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR

OverviewOverview

Tissue factor is a cell-surface glycoprotein receptor which initiates the, blood coagulation cascade after vessel injury by interacting with blood, clotting factor VII/VIIa and which is implicated in various pathological, processes. When bound to tissue factor, factor VII is readily converted to, the active protease factor VIIa by trace amounts of factors Xa, IXa or, VIIa. Human tissue factor consists of 263 residues, the first 219 of which, comprise the extracellular region. We have determined the crystal, structure of the extracellular region at a resolution of 2.2 A. Tissue, factor consists of two immunoglobulin-like domains associated through an, extensive, novel, interdomain interface region. The binding site for, factor VII lies at the interface region and involves residues from domain, 1 and an extended loop (binding 'finger') of domain 2. This is the first, reported structure of a representative of the class 2 cytokine receptor, family, which also includes interferon-alpha, interferon-gamma (refs 2, 3), and interleukin-10 (ref. 4) receptors.

About this StructureAbout this Structure

1BOY is a Single protein structure of sequence from Homo sapiens. Structure known Active Sites: 7A1, 7A2 and XA1. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the extracellular region of human tissue factor., Harlos K, Martin DM, O'Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tuddenham EG, Boys CW, Nature. 1994 Aug 25;370(6491):662-6. PMID:8065454

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	[[Category: initiator of blood coagulation in vertebrates]]		[[Category: initiator of blood coagulation in vertebrates]]

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