4ojk: Difference between revisions
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==Structure of the cGMP Dependent Protein Kinase II and Rab11b Complex== | ==Structure of the cGMP Dependent Protein Kinase II and Rab11b Complex== | ||
<StructureSection load='4ojk' size='340' side='right' caption='[[4ojk]], [[Resolution|resolution]] 2.66Å' scene=''> | <StructureSection load='4ojk' size='340' side='right' caption='[[4ojk]], [[Resolution|resolution]] 2.66Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zxa|1zxa]], [[3nmd|3nmd]], [[2f9l|2f9l]], [[2f9m|2f9m]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zxa|1zxa]], [[3nmd|3nmd]], [[2f9l|2f9l]], [[2f9m|2f9m]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Small_monomeric_GTPase Small monomeric GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Small_monomeric_GTPase Small monomeric GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ojk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ojk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ojk RCSB], [http://www.ebi.ac.uk/pdbsum/4ojk PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ojk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ojk OCA], [http://pdbe.org/4ojk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ojk RCSB], [http://www.ebi.ac.uk/pdbsum/4ojk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ojk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4ojk" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[GTP-binding protein|GTP-binding protein]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 22:00, 5 August 2016
Structure of the cGMP Dependent Protein Kinase II and Rab11b ComplexStructure of the cGMP Dependent Protein Kinase II and Rab11b Complex
Structural highlights
Function[RB11B_HUMAN] GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity). Publication Abstract from PubMedcGMP-dependent protein kinase (PKG)-interacting proteins (GKIPs) mediate cellular targeting of PKG isoforms by interacting with their leucine zipper (LZ) domains. These interactions prevent aberrant signaling cross-talk between different PKG isotypes. To gain detailed insight into isotype-specific GKIP recognition by PKG, we analyzed the type II PKG leucine zipper domain and found that residues 40-83 dimerized and specifically interacted with Rab11b. Next, we determined a crystal structure of the PKG II LZ-Rab11b complex. The PKG II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van der Waals interactions. Contact surfaces in Rab11b are found in switch I and II, interswitch, and the beta1/N-terminal regions. This binding surface dramatically differs from that seen in the Rab11 family of interacting protein complex structures. Structural comparison with PKG Ialpha and Ibeta LZs combined with mutagenic analysis reveals that GKIP recognition is mediated through surface charge interactions. Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions.,Reger AS, Yang MP, Koide-Yoshida S, Guo E, Mehta S, Yuasa K, Liu A, Casteel DE, Kim C J Biol Chem. 2014 Sep 12;289(37):25393-403. doi: 10.1074/jbc.M114.575894. Epub, 2014 Jul 28. PMID:25070890[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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