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==Crystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritima== | ==Crystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritima== | ||
<StructureSection load='3n0u' size='340' side='right' caption='[[3n0u]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='3n0u' size='340' side='right' caption='[[3n0u]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3n0u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3n0u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N0U FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ogg, Tm1821, TM_1821 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ogg, Tm1821, TM_1821 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n0u RCSB], [http://www.ebi.ac.uk/pdbsum/3n0u PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0u OCA], [http://pdbe.org/3n0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n0u RCSB], [http://www.ebi.ac.uk/pdbsum/3n0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n0u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Atcc 43589]] | ||
[[Category: Cooper, D R]] | [[Category: Cooper, D R]] | ||
[[Category: Derewenda, Z S]] | [[Category: Derewenda, Z S]] | ||
Revision as of 21:20, 5 August 2016
Crystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritimaCrystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritima
Structural highlights
Function[OGG1_THEMA] Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity). See Also |
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