1muj: Difference between revisions

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|ACTIVITY=  
|ACTIVITY=  
|GENE=  
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|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1muj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1muj OCA], [http://www.ebi.ac.uk/pdbsum/1muj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1muj RCSB]</span>
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[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Zhu, Y.]]
[[Category: Zhu, Y.]]
[[Category: NAG]]
[[Category: antigen]]
[[Category: antigen]]
[[Category: clip]]
[[Category: clip]]
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[[Category: peptide]]
[[Category: peptide]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:48:24 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:21:17 2008''

Revision as of 22:21, 30 March 2008

File:1muj.gif


PDB ID 1muj

Drag the structure with the mouse to rotate
, resolution 2.15Å
Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide


OverviewOverview

Association between the class II major histocompatibility complex (MHC) and the class II invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the MHC class II processing pathway. Here, we report the crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution. The structure of I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a similar conformation to peptides bound by other I-A alleles, reinforcing the notion that CLIP is presented as a conventional peptide antigen. When compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide displays a slightly different conformation and distinct interaction pattern with residues in I-A(b). In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix.

About this StructureAbout this Structure

1MUJ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:12589760

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