4b7z: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-methylphenyl)-methanesulfonamide== | ==Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-methylphenyl)-methanesulfonamide== | ||
<StructureSection load='4b7z' size='340' side='right' caption='[[4b7z]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4b7z' size='340' side='right' caption='[[4b7z]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4b7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4b7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B7Z FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=Q4Q:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-METHYLPHENYL)METHANESULFONAMIDE'>Q4Q</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=Q4Q:N-[2-(DIETHYLAMINO)ETHYL]-1-(4-METHYLPHENYL)METHANESULFONAMIDE'>Q4Q</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1c2b|1c2b]], [[1c2o|1c2o]], [[1j06|1j06]], [[1j07|1j07]], [[1ku6|1ku6]], [[1maa|1maa]], [[1mah|1mah]], [[1n5m|1n5m]], [[1n5r|1n5r]], [[1q83|1q83]], [[1q84|1q84]], [[2c0p|2c0p]], [[2c0q|2c0q]], [[2h9y|2h9y]], [[2ha0|2ha0]], [[2ha2|2ha2]], [[2ha3|2ha3]], [[2ha4|2ha4]], [[2ha5|2ha5]], [[2ha6|2ha6]], [[2ha7|2ha7]], [[2jey|2jey]], [[2jez|2jez]], [[2jf0|2jf0]], [[2jge|2jge]], [[2jgf|2jgf]], [[2jgg|2jgg]], [[2jgh|2jgh]], [[2jgi|2jgi]], [[2jgj|2jgj]], [[2jgk|2jgk]], [[2jgl|2jgl]], [[2jgm|2jgm]], [[2whp|2whp]], [[2whq|2whq]], [[2whr|2whr]], [[2wls|2wls]], [[2wu3|2wu3]], [[2wu4|2wu4]], [[2xud|2xud]], [[2xuf|2xuf]], [[2xug|2xug]], [[2xuh|2xuh]], [[2xui|2xui]], [[2xuj|2xuj]], [[2xuk|2xuk]], [[2xuo|2xuo]], [[2xup|2xup]], [[2xuq|2xuq]], [[4a16|4a16]], [[4a23|4a23]], [[4ara|4ara]], [[4arb|4arb]], [[4b80|4b80]], [[4b81|4b81]], [[4b82|4b82]], [[4b83|4b83]], [[4b84|4b84]], [[4b85|4b85]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1c2b|1c2b]], [[1c2o|1c2o]], [[1j06|1j06]], [[1j07|1j07]], [[1ku6|1ku6]], [[1maa|1maa]], [[1mah|1mah]], [[1n5m|1n5m]], [[1n5r|1n5r]], [[1q83|1q83]], [[1q84|1q84]], [[2c0p|2c0p]], [[2c0q|2c0q]], [[2h9y|2h9y]], [[2ha0|2ha0]], [[2ha2|2ha2]], [[2ha3|2ha3]], [[2ha4|2ha4]], [[2ha5|2ha5]], [[2ha6|2ha6]], [[2ha7|2ha7]], [[2jey|2jey]], [[2jez|2jez]], [[2jf0|2jf0]], [[2jge|2jge]], [[2jgf|2jgf]], [[2jgg|2jgg]], [[2jgh|2jgh]], [[2jgi|2jgi]], [[2jgj|2jgj]], [[2jgk|2jgk]], [[2jgl|2jgl]], [[2jgm|2jgm]], [[2whp|2whp]], [[2whq|2whq]], [[2whr|2whr]], [[2wls|2wls]], [[2wu3|2wu3]], [[2wu4|2wu4]], [[2xud|2xud]], [[2xuf|2xuf]], [[2xug|2xug]], [[2xuh|2xuh]], [[2xui|2xui]], [[2xuj|2xuj]], [[2xuk|2xuk]], [[2xuo|2xuo]], [[2xup|2xup]], [[2xuq|2xuq]], [[4a16|4a16]], [[4a23|4a23]], [[4ara|4ara]], [[4arb|4arb]], [[4b80|4b80]], [[4b81|4b81]], [[4b82|4b82]], [[4b83|4b83]], [[4b84|4b84]], [[4b85|4b85]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b7z RCSB], [http://www.ebi.ac.uk/pdbsum/4b7z PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7z OCA], [http://pdbe.org/4b7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b7z RCSB], [http://www.ebi.ac.uk/pdbsum/4b7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| Line 18: | Line 19: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4b7z" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Acetylcholinesterase|Acetylcholinesterase]] | *[[Acetylcholinesterase|Acetylcholinesterase]] | ||
*[[3D structures of acetylcholinesterase|3D structures of acetylcholinesterase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 26: | Line 29: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Akfur, C]] | [[Category: Akfur, C]] | ||
[[Category: Allgardsson, A]] | [[Category: Allgardsson, A]] | ||
Revision as of 21:05, 5 August 2016
Mus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-methylphenyl)-methanesulfonamideMus musculus Acetylcholinesterase in complex with N-(2-Diethylamino-ethyl)-1-(4-methylphenyl)-methanesulfonamide
Structural highlights
Function[ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Publication Abstract from PubMedThe molecular interactions between the enzyme acetylcholinesterase (AChE) and two compound classes consisting of N-[2-(diethylamino)-ethyl]-benzenesulfonamides and N-[2-(diethylamino)-ethyl]-benzenemethanesulfonamides have been investigated using organic synthesis, enzymatic assays, X-ray crystallography, and thermodynamic profiling. The inhibitors' aromatic properties were varied to establish structure-activity relationships (SAR) between the inhibitors and the peripheral anionic site (PAS) of AChE. The two structurally similar compound classes proved to have distinctly divergent SARs in terms of their inhibition capacity of AChE. Eight X-ray structures revealed that the two sets have different conformations in PAS. Furthermore, thermodynamic profiles of the binding between compounds and AChE revealed class-dependent differences of the entropy/enthalpy contributions to the free energy of binding. Further development of the entropy-favored compound class resulted in the synthesis of the most potent inhibitor, and an extension beyond the established SARs. The divergent SARs will be utilized to develop reversible inhibitors of AChE into reactivators of nerve agent inhibited AChE. Divergent Structure-Activity Relationships of Structurally Similar Acetylcholinesterase Inhibitors.,Andersson CD, Forsgren N, Akfur C, Allgardsson A, Berg L, Engdahl C, Qian W, Ekstrom FJ, Linusson A J Med Chem. 2013 Aug 28. PMID:23984975[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
|
| ||||||||||||||||||||