3p2r: Difference between revisions
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==Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate== | ==Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate== | ||
<StructureSection load='3p2r' size='340' side='right' caption='[[3p2r]], [[Resolution|resolution]] 2.46Å' scene=''> | <StructureSection load='3p2r' size='340' side='right' caption='[[3p2r]], [[Resolution|resolution]] 2.46Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3p2r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3p2r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_cattleya"_kahan_et_al._1979 "streptomyces cattleya" kahan et al. 1979]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P2R FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p2q|3p2q]], [[3p2s|3p2s]], [[3p3f|3p3f]], [[3p3i|3p3i]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p2q|3p2q]], [[3p2s|3p2s]], [[3p3f|3p3f]], [[3p3i|3p3i]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">flK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29303 Streptomyces cattleya])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">flK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29303 "Streptomyces cattleya" Kahan et al. 1979])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p2r RCSB], [http://www.ebi.ac.uk/pdbsum/3p2r PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2r OCA], [http://pdbe.org/3p2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p2r RCSB], [http://www.ebi.ac.uk/pdbsum/3p2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p2r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/ | [[http://www.uniprot.org/uniprot/FLK_STRCT FLK_STRCT]] Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Can not use acetyl-CoA as substrate.<ref>PMID:16720268</ref> <ref>PMID:20836570</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3p2r" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Streptomyces cattleya]] | [[Category: Streptomyces cattleya kahan et al. 1979]] | ||
[[Category: Chang, M C.Y]] | [[Category: Chang, M C.Y]] | ||
[[Category: Coyle, S M]] | [[Category: Coyle, S M]] |