2xd7: Difference between revisions
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==CRYSTAL STRUCTURE OF THE MACRO DOMAIN OF HUMAN CORE HISTONE H2A== | ==CRYSTAL STRUCTURE OF THE MACRO DOMAIN OF HUMAN CORE HISTONE H2A== | ||
<StructureSection load='2xd7' size='340' side='right' caption='[[2xd7]], [[Resolution|resolution]] 2.09Å' scene=''> | <StructureSection load='2xd7' size='340' side='right' caption='[[2xd7]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xd7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2xd7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XD7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xd7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xd7 PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xd7 OCA], [http://pdbe.org/2xd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xd7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xd7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xd7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xd7 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 16:04, 5 August 2016
CRYSTAL STRUCTURE OF THE MACRO DOMAIN OF HUMAN CORE HISTONE H2ACRYSTAL STRUCTURE OF THE MACRO DOMAIN OF HUMAN CORE HISTONE H2A
Structural highlights
Function[H2AW_HUMAN] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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