3ots: Difference between revisions
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==MDR769 HIV-1 protease complexed with MA/CA hepta-peptide== | ==MDR769 HIV-1 protease complexed with MA/CA hepta-peptide== | ||
<StructureSection load='3ots' size='340' side='right' caption='[[3ots]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='3ots' size='340' side='right' caption='[[3ots]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ots]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3ots]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OTS FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3oty|3oty]], [[3ou1|3ou1]], [[3ou3|3ou3]], [[3ou4|3ou4]], [[3oua|3oua]], [[3oub|3oub]], [[3ouc|3ouc]], [[3oud|3oud]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3oty|3oty]], [[3ou1|3ou1]], [[3ou3|3ou3]], [[3ou4|3ou4]], [[3oua|3oua]], [[3oub|3oub]], [[3ouc|3ouc]], [[3oud|3oud]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ots FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ots OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ots RCSB], [http://www.ebi.ac.uk/pdbsum/3ots PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ots FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ots OCA], [http://pdbe.org/3ots PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ots RCSB], [http://www.ebi.ac.uk/pdbsum/3ots PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ots ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3ots" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Brunzelle, J]] | [[Category: Brunzelle, J]] | ||
[[Category: Kovari, I A]] | [[Category: Kovari, I A]] | ||
Revision as of 15:09, 5 August 2016
MDR769 HIV-1 protease complexed with MA/CA hepta-peptideMDR769 HIV-1 protease complexed with MA/CA hepta-peptide
Structural highlights
Publication Abstract from PubMedUnder drug selection pressure, emerging mutations render HIV-1 protease drug resistant, leading to the therapy failure in anti-HIV treatment. It is known that nine substrate cleavage site peptides bind to wild type (WT) HIV-1 protease in a conserved pattern. However, how the multidrug-resistant (MDR) HIV-1 protease binds to the substrate cleavage site peptides is yet to be determined. MDR769 HIV-1 protease (resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90) was selected for present study to understand the binding to its natural substrates. MDR769 HIV-1 protease was co-crystallized with nine substrate cleavage site hepta-peptides. Crystallographic studies show that MDR769 HIV-1 protease has an expanded substrate envelope with wide open flaps. Furthermore, ligand binding energy calculations indicate weaker binding in MDR769 HIV-1 protease-substrate complexes. These results help in designing the next generation of HIV-1 protease inhibitors by targeting the MDR HIV-1 protease. Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.,Liu Z, Wang Y, Brunzelle J, Kovari IA, Kovari LC Protein J. 2011 Mar 12. PMID:21394574[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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