4kk2: Difference between revisions

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==Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure==
==Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure==
<StructureSection load='4kk2' size='340' side='right' caption='[[4kk2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4kk2' size='340' side='right' caption='[[4kk2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Artemisia_spiciformis Artemisia spiciformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KK2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4kk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Artsi Artsi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KK2 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDS-5, FDS-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235357 Artemisia spiciformis])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDS-5, FDS-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235357 ARTSI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4kk2 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk2 OCA], [http://pdbe.org/4kk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4kk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kk2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Artemisia spiciformis]]
[[Category: Artsi]]
[[Category: Almo, S C]]
[[Category: Almo, S C]]
[[Category: Bhosle, R]]
[[Category: Bhosle, R]]

Revision as of 14:15, 5 August 2016

Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structureCrystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure

Structural highlights

4kk2 is a 2 chain structure with sequence from Artsi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:FDS-5, FDS-1 (ARTSI)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CHRDS_ARTSI] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.[1]

References

  1. Hemmerlin A, Rivera SB, Erickson HK, Poulter CD. Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis. J Biol Chem. 2003 Aug 22;278(34):32132-40. Epub 2003 Jun 2. PMID:12782626 doi:10.1074/jbc.M213045200

4kk2, resolution 2.20Å

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