3she: Difference between revisions
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==Novel ATP-competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series== | ==Novel ATP-competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series== | ||
<StructureSection load='3she' size='340' side='right' caption='[[3she]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='3she' size='340' side='right' caption='[[3she]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3she]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3she]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SHE FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I85:N-{4-[(3S)-4-OXO-1,4,5,6-TETRAHYDROSPIRO[PIPERIDINE-3,7-PYRROLO[3,2-C]PYRIDIN]-2-YL]PYRIDIN-2-YL}-3-(TRIFLUOROMETHYL)BENZAMIDE'>I85</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I85:N-{4-[(3S)-4-OXO-1,4,5,6-TETRAHYDROSPIRO[PIPERIDINE-3,7-PYRROLO[3,2-C]PYRIDIN]-2-YL]PYRIDIN-2-YL}-3-(TRIFLUOROMETHYL)BENZAMIDE'>I85</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAPKAPK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAPKAPK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3she FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3she OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3she RCSB], [http://www.ebi.ac.uk/pdbsum/3she PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3she FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3she OCA], [http://pdbe.org/3she PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3she RCSB], [http://www.ebi.ac.uk/pdbsum/3she PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3she ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3she" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Kazemier, B]] | [[Category: Kazemier, B]] |