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==Cocrystal structure of a mutant class-I preQ1 riboswitch== | ==Cocrystal structure of a mutant class-I preQ1 riboswitch== | ||
<StructureSection load='3k1v' size='340' side='right' caption='[[3k1v]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='3k1v' size='340' side='right' caption='[[3k1v]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
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<table><tr><td colspan='2'>[[3k1v]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3fu4 3fu4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K1V FirstGlance]. <br> | <table><tr><td colspan='2'>[[3k1v]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3fu4 3fu4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K1V FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PRF:7-DEAZA-7-AMINOMETHYL-GUANINE'>PRF</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PRF:7-DEAZA-7-AMINOMETHYL-GUANINE'>PRF</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k1v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k1v RCSB], [http://www.ebi.ac.uk/pdbsum/3k1v PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k1v OCA], [http://pdbe.org/3k1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k1v RCSB], [http://www.ebi.ac.uk/pdbsum/3k1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k1v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3k1v" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
Revision as of 13:21, 5 August 2016
Cocrystal structure of a mutant class-I preQ1 riboswitchCocrystal structure of a mutant class-I preQ1 riboswitch
Structural highlights
Publication Abstract from PubMedRiboswitches are mRNA domains that bind metabolites and modulate gene expression in cis. We report cocrystal structures of a remarkably compact riboswitch (34 nucleotides suffice for ligand recognition) from Bacillus subtilis that is selective for the essential nucleobase preQ(1) (7-aminomethyl-7-deazaguanine). The structures reveal a previously unrecognized pseudoknot fold and suggest a conserved gene-regulatory mechanism whereby ligand binding promotes sequestration of an RNA segment that otherwise assembles into a transcriptional antiterminator. Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase.,Klein DJ, Edwards TE, Ferre-D'Amare AR Nat Struct Mol Biol. 2009 Mar;16(3):343-4. Epub 2009 Feb 22. PMID:19234468[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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