3oua: Difference between revisions
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==MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide== | ==MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide== | ||
<StructureSection load='3oua' size='340' side='right' caption='[[3oua]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='3oua' size='340' side='right' caption='[[3oua]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3oua]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3oua]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OUA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OUA FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3oty|3oty]], [[3ou1|3ou1]], [[3ou3|3ou3]], [[3ou4|3ou4]], [[3oub|3oub]], [[3ouc|3ouc]], [[3oud|3oud]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3oty|3oty]], [[3ou1|3ou1]], [[3ou3|3ou3]], [[3ou4|3ou4]], [[3oub|3oub]], [[3ouc|3ouc]], [[3oud|3oud]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oua OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oua RCSB], [http://www.ebi.ac.uk/pdbsum/3oua PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oua OCA], [http://pdbe.org/3oua PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oua RCSB], [http://www.ebi.ac.uk/pdbsum/3oua PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oua ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3oua" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Brunzelle, J]] | [[Category: Brunzelle, J]] | ||
[[Category: Kovari, I A]] | [[Category: Kovari, I A]] | ||
Revision as of 12:31, 5 August 2016
MDR769 HIV-1 protease complexed with p1/p6 hepta-peptideMDR769 HIV-1 protease complexed with p1/p6 hepta-peptide
Structural highlights
Function[Q9YP46_9HIV1] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS012344_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS012344_004_011858] Publication Abstract from PubMedUnder drug selection pressure, emerging mutations render HIV-1 protease drug resistant, leading to the therapy failure in anti-HIV treatment. It is known that nine substrate cleavage site peptides bind to wild type (WT) HIV-1 protease in a conserved pattern. However, how the multidrug-resistant (MDR) HIV-1 protease binds to the substrate cleavage site peptides is yet to be determined. MDR769 HIV-1 protease (resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90) was selected for present study to understand the binding to its natural substrates. MDR769 HIV-1 protease was co-crystallized with nine substrate cleavage site hepta-peptides. Crystallographic studies show that MDR769 HIV-1 protease has an expanded substrate envelope with wide open flaps. Furthermore, ligand binding energy calculations indicate weaker binding in MDR769 HIV-1 protease-substrate complexes. These results help in designing the next generation of HIV-1 protease inhibitors by targeting the MDR HIV-1 protease. Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.,Liu Z, Wang Y, Brunzelle J, Kovari IA, Kovari LC Protein J. 2011 Mar 12. PMID:21394574[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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