1m93: Difference between revisions
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|PDB= 1m93 |SIZE=350|CAPTION= <scene name='initialview01'>1m93</scene>, resolution 1.65Å | |PDB= 1m93 |SIZE=350|CAPTION= <scene name='initialview01'>1m93</scene>, resolution 1.65Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene> | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= crmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | |GENE= crmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10243 Cowpox virus]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1c8o|1C8O]], [[1f0c|1F0C]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m93 OCA], [http://www.ebi.ac.uk/pdbsum/1m93 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m93 RCSB]</span> | |||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
1M93 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | 1M93 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M93 OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition., Simonovic M, Gettins PGW, Volz K, Protein Sci. 2000 Aug;9(8):1423-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10975564 10975564] | Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition., Simonovic M, Gettins PGW, Volz K, Protein Sci. 2000 Aug;9(8):1423-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10975564 10975564] | ||
[[Category: | [[Category: Cowpox virus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Gettins, P G.W.]] | [[Category: Gettins, P G.W.]] | ||
[[Category: Simonovic, M.]] | [[Category: Simonovic, M.]] | ||
[[Category: Volz, K.]] | [[Category: Volz, K.]] | ||
[[Category: apoptosis]] | [[Category: apoptosis]] | ||
[[Category: crma]] | [[Category: crma]] | ||
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[[Category: serpin]] | [[Category: serpin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:13:04 2008'' | ||
Revision as of 22:13, 30 March 2008
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| , resolution 1.65Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | crmA (Cowpox virus) | ||||||
| Related: | 1C8O, 1F0C
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
1.65 A Structure of Cleaved Viral Serpin CRMA
OverviewOverview
CrmA is an unusual viral serpin that inhibits both cysteine and serine proteinases involved in the regulation of host inflammatory and apoptosis processes. It differs from other members of the serpin superfamily by having a reactive center loop that is one residue shorter, and by its apparent inability to form SDS-stable covalent complexes with cysteine proteinases. To obtain insight into the inhibitory mechanism of crmA, we determined the crystal structure of reactive center loop-cleaved crmA to 2.9 A resolution. The structure, which is the first of a viral serpin, suggests that crmA can inhibit cysteine proteinases by a mechanism analogous to that used by other serpins against serine proteinases. However, one striking difference from other serpins, which may be significant for in vivo function, is an additional highly charged antiparallel strand for b sheet A, whose sequence and length are unique to crmA.
About this StructureAbout this Structure
1M93 is a Protein complex structure of sequences from Cowpox virus. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition., Simonovic M, Gettins PGW, Volz K, Protein Sci. 2000 Aug;9(8):1423-7. PMID:10975564
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