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==Crystal Structure of Human Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha== | ==Crystal Structure of Human Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha== | ||
<StructureSection load='2ybx' size='340' side='right' caption='[[2ybx]], [[Resolution|resolution]] 2.56Å' scene=''> | <StructureSection load='2ybx' size='340' side='right' caption='[[2ybx]], [[Resolution|resolution]] 2.56Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ybx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ybx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YBX FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ybx RCSB], [http://www.ebi.ac.uk/pdbsum/2ybx PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybx OCA], [http://pdbe.org/2ybx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ybx RCSB], [http://www.ebi.ac.uk/pdbsum/2ybx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ybx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]] | [[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]] | ||
[[Category: | [[Category: Human]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Berglund, H]] | [[Category: Berglund, H]] | ||
Revision as of 10:19, 5 August 2016
Crystal Structure of Human Phosphatidylinositol-5-phosphate 4-kinase type-2 alphaCrystal Structure of Human Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
Structural highlights
Disease[PI42A_HUMAN] Precursor B-cell acute lymphoblastic leukemia. Function[PI42A_HUMAN] Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.[1] References
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- 1-phosphatidylinositol-5-phosphate 4-kinase
- Human
- Arrowsmith, C H
- Berglund, H
- Bountra, C
- Collins, R
- Edwards, A M
- Ekblad, T
- Flodin, S
- Graslund, S
- Karlberg, T
- Kotenyova, T
- Kouznetsova, E
- Moche, M
- Nordlund, P
- Nyman, T
- Persson, C
- Schuler, H
- Siponen, M I
- Thorsell, A G
- Tresaugues, L
- Wahlberg, E
- Weigelt, J
- Kinase
- Signalling
- Transferase