1m1r: Difference between revisions
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|PDB= 1m1r |SIZE=350|CAPTION= <scene name='initialview01'>1m1r</scene>, resolution 1.02Å | |PDB= 1m1r |SIZE=350|CAPTION= <scene name='initialview01'>1m1r</scene>, resolution 1.02Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1m1p|1M1P]], [[1m1q|1M1Q]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1r OCA], [http://www.ebi.ac.uk/pdbsum/1m1r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m1r RCSB]</span> | |||
}} | }} | ||
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[[Category: Nealson, K H.]] | [[Category: Nealson, K H.]] | ||
[[Category: Tsapin, A I.]] | [[Category: Tsapin, A I.]] | ||
[[Category: atomic resolution]] | [[Category: atomic resolution]] | ||
[[Category: reduced structure]] | [[Category: reduced structure]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:10:10 2008'' | ||
Revision as of 22:10, 30 March 2008
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| , resolution 1.02Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Related: | 1M1P, 1M1Q
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Reduced p222 crystal structure of the tetraheme cytochrome c of Shewanella oneidensis MR1
OverviewOverview
The genus Shewanella produces a unique small tetraheme cytochrome c that is implicated in the iron oxide respiration pathway. It is similar in heme content and redox potential to the well known cytochromes c(3) but related in structure to the cytochrome c domain of soluble fumarate reductases from Shewanella sp. We report the crystal structure of the small tetraheme cytochrome c from Shewanella oneidensis MR-1 in two crystal forms and two redox states. The overall fold and heme core are surprisingly different from the soluble fumarate reductase structures. The high resolution obtained for an oxidized orthorhombic crystal (0.97 A) revealed several flexible regions. Comparison of the six monomers in the oxidized monoclinic space group (1.55 A) indicates flexibility in the C-terminal region containing heme IV. The reduced orthorhombic crystal structure (1.02 A) revealed subtle differences in the position of several residues, resulting in decreased solvent accessibility of hemes and the withdrawal of a positive charge from the molecular surface. The packing between monomers indicates that intermolecular electron transfer between any heme pair is possible. This suggests there is no unique site of electron transfer on the surface of the protein and that electron transfer partners may interact with any of the hemes, a process termed "electron-harvesting." This optimizes the efficiency of intermolecular electron transfer by maximizing chances of productive collision with redox partners.
About this StructureAbout this Structure
1M1R is a Single protein structure of sequence from Shewanella oneidensis. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures at atomic resolution reveal the novel concept of "electron-harvesting" as a role for the small tetraheme cytochrome c., Leys D, Meyer TE, Tsapin AS, Nealson KH, Cusanovich MA, Van Beeumen JJ, J Biol Chem. 2002 Sep 20;277(38):35703-11. Epub 2002 Jun 21. PMID:12080059
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