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==Crystal structure of DNA ligase A BRCT domain deleted mutant of Mycobacterium tuberculosis== | ==Crystal structure of DNA ligase A BRCT domain deleted mutant of Mycobacterium tuberculosis== | ||
<StructureSection load='3sgi' size='340' side='right' caption='[[3sgi]], [[Resolution|resolution]] 3.50Å' scene=''> | <StructureSection load='3sgi' size='340' side='right' caption='[[3sgi]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3sgi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3sgi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SGI FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zau|1zau]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zau|1zau]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lig, ligA, MT3094, MTV012.28c, Rv3014c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lig, ligA, MT3094, MTV012.28c, Rv3014c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sgi RCSB], [http://www.ebi.ac.uk/pdbsum/3sgi PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgi OCA], [http://pdbe.org/3sgi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sgi RCSB], [http://www.ebi.ac.uk/pdbsum/3sgi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Kukshal, V]] | [[Category: Kukshal, V]] | ||
[[Category: Ravishankar, R]] | [[Category: Ravishankar, R]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Nad depndent dna ligase some]] | [[Category: Nad depndent dna ligase some]] | ||
Revision as of 05:56, 5 August 2016
Crystal structure of DNA ligase A BRCT domain deleted mutant of Mycobacterium tuberculosisCrystal structure of DNA ligase A BRCT domain deleted mutant of Mycobacterium tuberculosis
Structural highlights
Function[DNLJ_MYCTU] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.[HAMAP-Rule:MF_01588] See Also |
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