4c8d: Difference between revisions
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==Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)== | ==Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)== | ||
<StructureSection load='4c8d' size='340' side='right' caption='[[4c8d]], [[Resolution|resolution]] 2.18Å' scene=''> | <StructureSection load='4c8d' size='340' side='right' caption='[[4c8d]], [[Resolution|resolution]] 2.18Å' scene=''> | ||
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<table><tr><td colspan='2'>[[4c8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8D FirstGlance]. <br> | <table><tr><td colspan='2'>[[4c8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8D FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c8d RCSB], [http://www.ebi.ac.uk/pdbsum/4c8d PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8d OCA], [http://pdbe.org/4c8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c8d RCSB], [http://www.ebi.ac.uk/pdbsum/4c8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8d ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/KDM3B_HUMAN KDM3B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.<ref>PMID:16603237</ref> | [[http://www.uniprot.org/uniprot/KDM3B_HUMAN KDM3B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.<ref>PMID:16603237</ref> | ||
==See Also== | |||
*[[Jumonji domain-containing protein|Jumonji domain-containing protein]] | |||
== References == | == References == | ||
<references/> | <references/> | ||