4dyb: Difference between revisions
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==Crystal Structure of WSN/A Influenza Nucleoprotein with BMS-883559 Ligand Bound== | ==Crystal Structure of WSN/A Influenza Nucleoprotein with BMS-883559 Ligand Bound== | ||
<StructureSection load='4dyb' size='340' side='right' caption='[[4dyb]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='4dyb' size='340' side='right' caption='[[4dyb]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dya|4dya]], [[4dyn|4dyn]], [[4dyp|4dyp]], [[4dys|4dys]], [[4dyt|4dyt]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dya|4dya]], [[4dyn|4dyn]], [[4dyp|4dyp]], [[4dys|4dys]], [[4dyt|4dyt]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=382835 Influenza A virus (A/WSN/1933(H1N1))])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=382835 Influenza A virus (A/WSN/1933(H1N1))])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dyb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dyb RCSB], [http://www.ebi.ac.uk/pdbsum/4dyb PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dyb OCA], [http://pdbe.org/4dyb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dyb RCSB], [http://www.ebi.ac.uk/pdbsum/4dyb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dyb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
Revision as of 02:16, 5 August 2016
Crystal Structure of WSN/A Influenza Nucleoprotein with BMS-883559 Ligand BoundCrystal Structure of WSN/A Influenza Nucleoprotein with BMS-883559 Ligand Bound
Structural highlights
Function[B4URF1_9INFA] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.[SAAS:SAAS00107710] See Also |
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