1lc2: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
|PDB= 1lc2 |SIZE=350|CAPTION= <scene name='initialview01'>1lc2</scene> | |PDB= 1lc2 |SIZE=350|CAPTION= <scene name='initialview01'>1lc2</scene> | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=HEC:HEME C'>HEC</scene> | |LIGAND= <scene name='pdbligand=HEC:HEME+C'>HEC</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1lc1|1LC1]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lc2 OCA], [http://www.ebi.ac.uk/pdbsum/1lc2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lc2 RCSB]</span> | |||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Mabrouk, P A.]] | [[Category: Mabrouk, P A.]] | ||
[[Category: Sivakolundu, S G.]] | [[Category: Sivakolundu, S G.]] | ||
[[Category: cytochrome c]] | [[Category: cytochrome c]] | ||
[[Category: organic solvent]] | [[Category: organic solvent]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:00:54 2008'' | ||
Revision as of 22:00, 30 March 2008
| |||||||
| Ligands: | |||||||
| Related: | 1LC1
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure Of Reduced Horse Heart Cytochrome c in 30% Acetonitrile Solution, NMR 30 Structures
OverviewOverview
The complete solution structure of ferrocytochrome c in 30% acetonitrile/70% water has been determined using high-field 1D and 2D (1)H NMR methods and deposited in the Protein Data Bank with codes 1LC1 and 1LC2. This is the first time a complete solution protein structure has been determined for a protein in nonaqueous media. Ferrocyt c retains a native protein secondary structure (five alpha-helices and two omega loops) in 30% acetonitrile. H18 and M80 residues are the axial heme ligands, as in aqueous solution. Residues believed to be axial heme ligands in the alkaline-like conformers of ferricyt c, specifically H33 and K72, are positioned close to the heme iron. The orientations of both heme propionates are markedly different in 30% acetonitrile/70% water. Comparative structural analysis of reduced cyt c in 30% acetonitrile/70% water solution with cyt c in different environments has given new insight into the cyt c folding mechanism, the electron transfer pathway, and cell apoptosis.
About this StructureAbout this Structure
1LC2 is a Single protein structure of sequence from Equus caballus. Full crystallographic information is available from OCA.
ReferenceReference
Structure-function relationship of reduced cytochrome c probed by complete solution structure determination in 30% acetonitrile/water solution., Sivakolundu SG, Mabrouk PA, J Biol Inorg Chem. 2003 May;8(5):527-39. Epub 2003 Feb 15. PMID:12764601
Page seeded by OCA on Sun Mar 30 22:00:54 2008