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==CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR== | ==CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR== | ||
<StructureSection load='2who' size='340' side='right' caption='[[2who]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2who' size='340' side='right' caption='[[2who]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2who]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2who]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcv Hcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WHO FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=VGI:2-(3-BROMOPHENYL)-6-[(2-HYDROXYETHYL)AMINO]-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONE'>VGI</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=VGI:2-(3-BROMOPHENYL)-6-[(2-HYDROXYETHYL)AMINO]-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONE'>VGI</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhu|1nhu]], [[2i1r|2i1r]], [[2wcx|2wcx]], [[1jxp|1jxp]], [[1gx6|1gx6]], [[2jc1|2jc1]], [[8ohm|8ohm]], [[1c2p|1c2p]], [[1a1q|1a1q]], [[1cu1|1cu1]], [[1bt7|1bt7]], [[2jc0|2jc0]], [[2ax1|2ax1]], [[1ns3|1ns3]], [[1csj|1csj]], [[1nhv|1nhv]], [[1gx5|1gx5]], [[2brk|2brk]], [[2brl|2brl]], [[2ax0|2ax0]], [[2awz|2awz]], [[1quv|1quv]], [[1os5|1os5]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhu|1nhu]], [[2i1r|2i1r]], [[2wcx|2wcx]], [[1jxp|1jxp]], [[1gx6|1gx6]], [[2jc1|2jc1]], [[8ohm|8ohm]], [[1c2p|1c2p]], [[1a1q|1a1q]], [[1cu1|1cu1]], [[1bt7|1bt7]], [[2jc0|2jc0]], [[2ax1|2ax1]], [[1ns3|1ns3]], [[1csj|1csj]], [[1nhv|1nhv]], [[1gx5|1gx5]], [[2brk|2brk]], [[2brl|2brl]], [[2ax0|2ax0]], [[2awz|2awz]], [[1quv|1quv]], [[1os5|1os5]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2who FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2who OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2who RCSB], [http://www.ebi.ac.uk/pdbsum/2who PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2who FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2who OCA], [http://pdbe.org/2who PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2who RCSB], [http://www.ebi.ac.uk/pdbsum/2who PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2who ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2who" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Hcv]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
[[Category: Marco, S Di]] | [[Category: Marco, S Di]] | ||
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[[Category: Envelope protein]] | [[Category: Envelope protein]] | ||
[[Category: Genotype 1b]] | [[Category: Genotype 1b]] | ||
[[Category: Helicase]] | [[Category: Helicase]] | ||
[[Category: Hepatitis c virus]] | |||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Membrane]] | [[Category: Membrane]] |