3sb0: Difference between revisions
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==Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid inhibitor== | ==Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid inhibitor== | ||
<StructureSection load='3sb0' size='340' side='right' caption='[[3sb0]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='3sb0' size='340' side='right' caption='[[3sb0]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3sb0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3sb0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SB0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SB0 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I93:4-(2-CHLORO-6-FLUORO-3-METHYLPHENYL)-2,4-DIOXOBUTANOIC+ACID'>I93</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I93:4-(2-CHLORO-6-FLUORO-3-METHYLPHENYL)-2,4-DIOXOBUTANOIC+ACID'>I93</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1n8i|1n8i]], [[1n8w|1n8w]], [[3saz|3saz]], [[3s9i|3s9i]], [[3s9z|3s9z]], [[3sad|3sad]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1n8i|1n8i]], [[1n8w|1n8w]], [[3saz|3saz]], [[3s9i|3s9i]], [[3s9z|3s9z]], [[3sad|3sad]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glcB, GlcB (Rv1837c), MT1885, MTCY1A11.06, Rv1837c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glcB, GlcB (Rv1837c), MT1885, MTCY1A11.06, Rv1837c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malate_synthase Malate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.9 2.3.3.9] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malate_synthase Malate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.9 2.3.3.9] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sb0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sb0 RCSB], [http://www.ebi.ac.uk/pdbsum/3sb0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sb0 OCA], [http://pdbe.org/3sb0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sb0 RCSB], [http://www.ebi.ac.uk/pdbsum/3sb0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sb0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3sb0" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Malate synthase]] | [[Category: Malate synthase]] | ||
[[Category: Krieger, I V]] | [[Category: Krieger, I V]] | ||
[[Category: Sacchettini, J C]] | [[Category: Sacchettini, J C]] |