4m4c: Difference between revisions
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==Crystal structure of Rhodostomin ARGDP mutant== | ==Crystal structure of Rhodostomin ARGDP mutant== | ||
<StructureSection load='4m4c' size='340' side='right' caption='[[4m4c]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4m4c' size='340' side='right' caption='[[4m4c]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
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<table><tr><td colspan='2'>[[4m4c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M4C FirstGlance]. <br> | <table><tr><td colspan='2'>[[4m4c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M4C FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m4c RCSB], [http://www.ebi.ac.uk/pdbsum/4m4c PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4c OCA], [http://pdbe.org/4m4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m4c RCSB], [http://www.ebi.ac.uk/pdbsum/4m4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
Revision as of 20:19, 4 August 2016
Crystal structure of Rhodostomin ARGDP mutantCrystal structure of Rhodostomin ARGDP mutant
Structural highlights
Function[VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). |
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