3a5p: Difference between revisions
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==Crystal structure of hemagglutinin== | ==Crystal structure of hemagglutinin== | ||
<StructureSection load='3a5p' size='340' side='right' caption='[[3a5p]], [[Resolution|resolution]] 1.82Å' scene=''> | <StructureSection load='3a5p' size='340' side='right' caption='[[3a5p]], [[Resolution|resolution]] 1.82Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3a5p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Phypo Phypo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A5P FirstGlance]. <br> | <table><tr><td colspan='2'>[[3a5p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Phypo Phypo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A5P FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a5p RCSB], [http://www.ebi.ac.uk/pdbsum/3a5p PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5p OCA], [http://pdbe.org/3a5p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a5p RCSB], [http://www.ebi.ac.uk/pdbsum/3a5p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5p ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3a5p" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
Revision as of 20:17, 4 August 2016
Crystal structure of hemagglutininCrystal structure of hemagglutinin
Structural highlights
Publication Abstract from PubMedPhysarum polycephalum hemagglutinin I (HA1) is a 104-residue protein that is secreted to extracellular space. The crystal structure of HA1 has a beta-sandwich fold found among lectin structures, such as legume lectins and galectins. Interestingly, the beta-sandwich of HA1 lacks a jelly roll motif and is essentially composed of two simple up-and-down beta-sheets. This up-and-down beta-sheet motif is well conserved in other legume lectin-like proteins derived from animals, plants, bacteria, and viruses. It is more noteworthy that the up-and-down beta-sheet motif includes many residues that make contact with the target carbohydrates. Our NMR data demonstrate that HA1 lacking a jelly roll motif also binds to its target glycopeptide. Taken together, these data show that the up-and-down beta-sheet motif provides a fundamental scaffold for the binding of legume lectin-like proteins to the target carbohydrates, and the structure of HA1 suggests a minimal carbohydrate recognition domain. The Structure of Physarum polycephalum Hemagglutinin I Suggests a Minimal Carbohydrate Recognition Domain of Legume Lectin Fold.,Kouno T, Watanabe N, Sakai N, Nakamura T, Nabeshima Y, Morita M, Mizuguchi M, Aizawa T, Demura M, Imanaka T, Tanaka I, Kawano K J Mol Biol. 2010 Nov 20. PMID:21094650[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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