4j6m: Difference between revisions
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==Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)== | ==Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)== | ||
<StructureSection load='4j6m' size='340' side='right' caption='[[4j6m]], [[Resolution|resolution]] 2.48Å' scene=''> | <StructureSection load='4j6m' size='340' side='right' caption='[[4j6m]], [[Resolution|resolution]] 2.48Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4j6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4j6m]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J6M FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g96|4g96]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g96|4g96]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD23A, CLEC4J, FCE2, FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD23A, CLEC4J, FCE2, FCER2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j6m RCSB], [http://www.ebi.ac.uk/pdbsum/4j6m PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j6m OCA], [http://pdbe.org/4j6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j6m RCSB], [http://www.ebi.ac.uk/pdbsum/4j6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j6m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4j6m" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Dhaliwal, B]] | [[Category: Dhaliwal, B]] | ||
[[Category: Fabiane, S M]] | [[Category: Fabiane, S M]] | ||
Revision as of 19:58, 4 August 2016
Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)
Structural highlights
Function[FCER2_HUMAN] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). Publication Abstract from PubMedIgE antibodies play a central role in allergic disease. They recognize allergens via their Fab regions, whilst their effector functions are controlled through interactions of the Fc region with two principal cell surface receptors, FcvarepsilonRI and CD23. Crosslinking of FcvarepsilonRI-bound IgE on mast cells and basophils by allergen initiates an immediate inflammatory response, while the interaction of IgE with CD23 on B-cells regulates IgE production. We have determined the structures of the C-type lectin "head" domain of CD23 from seven crystal forms. The thirty-five independent structures reveal extensive conformational plasticity in two loops that are critical for IgE binding. Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.,Dhaliwal B, Pang MO, Yuan D, Yahya N, Fabiane SM, McDonnell JM, Gould HJ, Beavil AJ, Sutton BJ Mol Immunol. 2013 Aug 6;56(4):693-697. doi: 10.1016/j.molimm.2013.07.005. PMID:23933509[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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