3fu2: Difference between revisions
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==Cocrystal structure of a class-I preQ1 riboswitch== | ==Cocrystal structure of a class-I preQ1 riboswitch== | ||
<StructureSection load='3fu2' size='340' side='right' caption='[[3fu2]], [[Resolution|resolution]] 2.85Å' scene=''> | <StructureSection load='3fu2' size='340' side='right' caption='[[3fu2]], [[Resolution|resolution]] 2.85Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PRF:7-DEAZA-7-AMINOMETHYL-GUANINE'>PRF</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PRF:7-DEAZA-7-AMINOMETHYL-GUANINE'>PRF</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fu4|3fu4]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fu4|3fu4]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fu2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fu2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fu2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fu2 OCA], [http://pdbe.org/3fu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fu2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fu2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3fu2" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
Revision as of 16:58, 4 August 2016
Cocrystal structure of a class-I preQ1 riboswitchCocrystal structure of a class-I preQ1 riboswitch
Structural highlights
Publication Abstract from PubMedRiboswitches are mRNA domains that bind metabolites and modulate gene expression in cis. We report cocrystal structures of a remarkably compact riboswitch (34 nucleotides suffice for ligand recognition) from Bacillus subtilis that is selective for the essential nucleobase preQ(1) (7-aminomethyl-7-deazaguanine). The structures reveal a previously unrecognized pseudoknot fold and suggest a conserved gene-regulatory mechanism whereby ligand binding promotes sequestration of an RNA segment that otherwise assembles into a transcriptional antiterminator. Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase.,Klein DJ, Edwards TE, Ferre-D'Amare AR Nat Struct Mol Biol. 2009 Mar;16(3):343-4. Epub 2009 Feb 22. PMID:19234468[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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