4l0l: Difference between revisions
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==Crystal structure of P.aeruginosa PBP3 in complex with compound 4== | ==Crystal structure of P.aeruginosa PBP3 in complex with compound 4== | ||
<StructureSection load='4l0l' size='340' side='right' caption='[[4l0l]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='4l0l' size='340' side='right' caption='[[4l0l]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PFV:(6R,7S,10Z)-10-(2-AMINO-1,3-THIAZOL-4-YL)-1-(1,5-DIHYDROXY-4-OXO-1,4-DIHYDROPYRIDIN-2-YL)-7-FORMYL-13,13-DIMETHYL-3,9-DIOXO-6-(SULFOAMINO)-12-OXA-2,4,8,11-TETRAAZATETRADEC-10-EN-14-OIC+ACID'>PFV</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PFV:(6R,7S,10Z)-10-(2-AMINO-1,3-THIAZOL-4-YL)-1-(1,5-DIHYDROXY-4-OXO-1,4-DIHYDROPYRIDIN-2-YL)-7-FORMYL-13,13-DIMETHYL-3,9-DIOXO-6-(SULFOAMINO)-12-OXA-2,4,8,11-TETRAAZATETRADEC-10-EN-14-OIC+ACID'>PFV</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pbpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pbpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l0l RCSB], [http://www.ebi.ac.uk/pdbsum/4l0l PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0l OCA], [http://pdbe.org/4l0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l0l RCSB], [http://www.ebi.ac.uk/pdbsum/4l0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l0l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4l0l" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
Revision as of 15:52, 4 August 2016
Crystal structure of P.aeruginosa PBP3 in complex with compound 4Crystal structure of P.aeruginosa PBP3 in complex with compound 4
Structural highlights
Publication Abstract from PubMedHerein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa , Klebsiella pneumoniae , and Escherichia coli . Rat pharmacokinetic studies with compound 17 demonstrate low clearance and low plasma protein binding. In addition, evidence is provided for a number of analogues suggesting that the siderophore receptors PiuA and PirA play a role in drug uptake in P. aeruginosa strain PAO1. Pyridone-Conjugated Monobactam Antibiotics with Gram-Negative Activity.,Brown MF, Mitton-Fry MJ, Arcari JT, Barham R, Casavant J, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Lall MS, Lemmon MM, Li C, Lin J, McCurdy SP, McElroy E, McPherson C, Marr ES, Mueller JP, Mullins L, Nikitenko AA, Noe MC, Penzien J, Plummer MS, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Tomaras A, Young JA, Zaniewski RP J Med Chem. 2013 Jun 27. PMID:23755848[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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