4fad: Difference between revisions
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==Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3Ka and mTOR== | ==Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3Ka and mTOR== | ||
<StructureSection load='4fad' size='340' side='right' caption='[[4fad]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='4fad' size='340' side='right' caption='[[4fad]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4fad]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4fad]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FAD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FAD FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0TB:2-AMINO-6-(5-FLUORO-6-METHOXYPYRIDIN-3-YL)-4-METHYL-8-(PYRROLIDIN-1-YL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE'>0TB</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0TB:2-AMINO-6-(5-FLUORO-6-METHOXYPYRIDIN-3-YL)-4-METHYL-8-(PYRROLIDIN-1-YL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE'>0TB</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fa6|4fa6]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fa6|4fa6]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIK3CG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIK3CG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fad OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fad RCSB], [http://www.ebi.ac.uk/pdbsum/4fad PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fad OCA], [http://pdbe.org/4fad PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fad RCSB], [http://www.ebi.ac.uk/pdbsum/4fad PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fad ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4fad" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Greasley, S E]] | [[Category: Greasley, S E]] | ||
[[Category: Knighton, D R]] | [[Category: Knighton, D R]] | ||