1kjw: Difference between revisions
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|PDB= 1kjw |SIZE=350|CAPTION= <scene name='initialview01'>1kjw</scene>, resolution 1.8Å | |PDB= 1kjw |SIZE=350|CAPTION= <scene name='initialview01'>1kjw</scene>, resolution 1.8Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kjw OCA], [http://www.ebi.ac.uk/pdbsum/1kjw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kjw RCSB]</span> | |||
}} | }} | ||
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[[Category: Olsen, O.]] | [[Category: Olsen, O.]] | ||
[[Category: Prehoda, K E.]] | [[Category: Prehoda, K E.]] | ||
[[Category: protein-protein interaction]] | [[Category: protein-protein interaction]] | ||
[[Category: scaffold]] | [[Category: scaffold]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:49:39 2008'' | ||
Revision as of 21:49, 30 March 2008
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| , resolution 1.8Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SH3-Guanylate Kinase Module from PSD-95
OverviewOverview
Membrane-associated guanylate kinases (MAGUKs), such as PSD-95, are modular scaffolds that organize signaling complexes at synapses and other cell junctions. MAGUKs contain PDZ domains, which recruit signaling proteins, as well as a Src homology 3 (SH3) and a guanylate kinase-like (GK) domain, implicated in scaffold oligomerization. The crystal structure of the SH3-GK module from PSD-95 reveals that these domains form an integrated unit: the SH3 fold comprises noncontiguous sequence elements divided by a hinge region and the GK domain. These elements compose two subdomains that can assemble in either an intra- or intermolecular fashion to complete the SH3 fold. We propose a model for MAGUK oligomerization in which complementary SH3 subdomains associate by 3D domain swapping. This model provides a possible mechanism for ligand regulation of oligomerization.
About this StructureAbout this Structure
1KJW is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins., McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE, Mol Cell. 2001 Dec;8(6):1291-301. PMID:11779504
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