5jrt: Difference between revisions

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-'''Unreleased structure'''
-The entry 5jrt is ON HOLD  until Paper Publication
+==Crystal structure of the human Tankyrase 2 (TNKS2) SAM domain (DH902/924RE)==
+<StructureSection load='5jrt' size='340' side='right' caption='[[5jrt]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
-Authors: Guettler, S., Mariotti, L., Cronin, N.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5jrt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JRT FirstGlance]. <br>
-Description: Crystal structure of the human Tankyrase 2 (TNKS2) SAM domain (DH902/924RE)
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jrt OCA], [http://pdbe.org/5jrt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jrt RCSB], [http://www.ebi.ac.uk/pdbsum/5jrt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jrt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Cronin, N]]
 [[Category: Guettler, S]]
 [[Category: Mariotti, L]]
+[[Category: Signaling protein]]
+[[Category: Signalling protein]]
+[[Category: Transferase]]