5cui: Difference between revisions

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'''Unreleased structure'''


The entry 5cui is ON HOLD  until Paper Publication
==Crystal structure of Human Defensin-5 R28A mutant.==
 
<StructureSection load='5cui' size='340' side='right' caption='[[5cui]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Tolbert, W.D., Gohain, N., Pazgier, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5cui]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CUI FirstGlance]. <br>
Description: Crystal structure of Human Defensin-5 R28A mutant.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zmp|1zmp]], [[5cuj|5cuj]], [[5cum|5cum]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cui OCA], [http://pdbe.org/5cui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cui RCSB], [http://www.ebi.ac.uk/pdbsum/5cui PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cui ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN]] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gohain, N]]
[[Category: Pazgier, M]]
[[Category: Pazgier, M]]
[[Category: Tolbert, W.D]]
[[Category: Tolbert, W D]]
[[Category: Gohain, N]]
[[Category: Antimicrobial protein]]
[[Category: Human alpha-defensin]]
[[Category: Intestinal defensin]]
[[Category: Paneth cells defensin]]

Revision as of 18:36, 27 July 2016

Crystal structure of Human Defensin-5 R28A mutant.Crystal structure of Human Defensin-5 R28A mutant.

Structural highlights

5cui is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DEF5_HUMAN] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.[1] [2] [3]

References

  1. ↑ Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002 Jun;3(6):583-90. Epub 2002 May 20. PMID:12021776 doi:10.1038/ni797
  2. ↑ Ericksen B, Wu Z, Lu W, Lehrer RI. Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-75. PMID:15616305 doi:10.1128/AAC.49.1.269-275.2005
  3. ↑ Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J. Crystal structures of human alpha-defensins HNP4, HD5, and HD6. Protein Sci. 2006 Dec;15(12):2749-60. Epub 2006 Nov 6. PMID:17088326 doi:ps.062336606

5cui, resolution 2.40Å

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OCA
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