5cu9: Difference between revisions

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'''Unreleased structure'''


The entry 5cu9 is ON HOLD  until Paper Publication
==CANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APO==
 
<StructureSection load='5cu9' size='340' side='right' caption='[[5cu9]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
Authors: Waninger-Saroni, J.J., Taylor, A.B., Hart, P.J., Galaleldeen, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5cu9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CU9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CU9 FirstGlance]. <br>
Description: CANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APO
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n3t|4n3t]], [[4n3u|4n3u]]</td></tr>
[[Category: Hart, P.J]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
[[Category: Waninger-Saroni, J.J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cu9 OCA], [http://pdbe.org/5cu9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cu9 RCSB], [http://www.ebi.ac.uk/pdbsum/5cu9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cu9 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/SOD5_CANAL SOD5_CANAL]] Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.<ref>PMID:14617819</ref> <ref>PMID:19019164</ref> <ref>PMID:21746956</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Superoxide dismutase]]
[[Category: Galaleldeen, A]]
[[Category: Galaleldeen, A]]
[[Category: Taylor, A.B]]
[[Category: Hart, P J]]
[[Category: Taylor, A B]]
[[Category: Waninger-Saroni, J J]]
[[Category: Antioxidant]]
[[Category: Disulfide bond]]
[[Category: Extracellular]]
[[Category: Oxidative burst]]
[[Category: Oxidoreductase]]
[[Category: Zinc loop]]

Revision as of 18:36, 27 July 2016

CANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APOCANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APO

Structural highlights

5cu9 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:Superoxide dismutase, with EC number 1.15.1.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SOD5_CANAL] Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.[1] [2] [3]

References

  1. ↑ Martchenko M, Alarco AM, Harcus D, Whiteway M. Superoxide dismutases in Candida albicans: transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene. Mol Biol Cell. 2004 Feb;15(2):456-67. Epub 2003 Nov 14. PMID:14617819 doi:http://dx.doi.org/10.1091/mbc.E03-03-0179
  2. ↑ Frohner IE, Bourgeois C, Yatsyk K, Majer O, Kuchler K. Candida albicans cell surface superoxide dismutases degrade host-derived reactive oxygen species to escape innate immune surveillance. Mol Microbiol. 2009 Jan;71(1):240-52. doi: 10.1111/j.1365-2958.2008.06528.x. Epub, 2008 Nov 4. PMID:19019164 doi:http://dx.doi.org/10.1111/j.1365-2958.2008.06528.x
  3. ↑ Bink A, Vandenbosch D, Coenye T, Nelis H, Cammue BP, Thevissen K. Superoxide dismutases are involved in Candida albicans biofilm persistence against miconazole. Antimicrob Agents Chemother. 2011 Sep;55(9):4033-7. doi: 10.1128/AAC.00280-11., Epub 2011 Jul 11. PMID:21746956 doi:http://dx.doi.org/10.1128/AAC.00280-11

5cu9, resolution 1.48Å

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